Steven Kernie

Steven Kernie Columbia University
Associate Professor
Homepage
MD

Compare

vs.

Go

Research Summary

The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. It is, however, unclear what role, if any, adult neural stem cells play in contributing to post-injury recovery. We are interested in defining how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes that might be important in augmenting their contribution. The hippocampus is central to the formation of memory and has recently been implicated in higher cognitive functioning as well. In all mammals, the one area of the hippocampus that has constant neuronal turnover due to a persistent population of neural stem and progenitor cells is the dentate gyrus. The dentate gyrus functions to integrate cortical input and transmit this to other areas of the hippocampus. We study how the dentate gyrus develops and responds to injury such as trauma and hypoxia at varying ages. In order to do this, we have taken a genetic approach in mice that allows us to trace stem and progenitor cells within the hippocampus and gives us the ability to perform temporally specified genetic changes. We have developed a variety of tools to do this including tetracycline, tamoxifen, and ganciclovir-based systems that allow for fate labeling, progenitor ablation, and temporally and spatially regulated genetic deletions. Moreover, the addition of fluorescent tags in these transgenics allows us to quantify the number of adult neural stem cells during development and activated by injury by utilizing fluorescent activated cell sorting (FACS). These models make up the foundation to our lab?s approach of understanding how neural stem and progenitor cells may contribute to recovery following acquired brain injury.

Similar Researchers

Columbia University
New York, NY
Profile
Percentiles
Citations
33rd
Papers
55th
Funding
36th
Neuroscience, Tools & Methods, Learning & Memory, Synapses & Circuits, Cognition, Theoretical Neuroscience
Columbia University
New York, NY
Profile
Percentiles
Citations
33rd
Papers
46th
Funding
28th
Cell Biology, Cell Specification & Differentiation, Microbial Biology, Molecular Biophysics
Columbia University
New York, NY
Profile
Percentiles
Citations
44th
Papers
46th
Funding
26th
Cancer, Dermatology, Developmental Biology, Cell Division & Mitosis, Immunology, Cell Adhesion Molecules...
Columbia University
New York, NY
Profile
Percentiles
Citations
50th
Papers
54th
Funding
48th
Genomics & Genetics, Cancer, Mouse Biology, Developmental Biology, Cell Division & Mitosis...
Rockefeller University
New York, NY
Profile
Percentiles
Citations
41st
Papers
35th
Funding
30th
Immunology, Cancer, Tools & Methods, Biochemistry

Percentiles

Citations*
50th
Papers*
51st
Funding
32nd
Efficiency
50th

Today's Citations vs.
Paper Publication Year*

-

Funding by Source
2012-2015

-
*Cited papers in our current database **Coming soon